Studi SharPei

Increased HAS2-driven hyaluronic acid synthesis in shar-pei dogs with hereditary cutaneous hyaluronosis (mucinosis)

María José Docampo, Giordana Zanna, Dolors Fondevila, Jennifer Cabrera, Carmen López-Iglesias, Andrea Carvalho, Santiago Cerrato, Lluís Ferrer and Anna Bassols Veterinary Dermatology Volume 22, Issue 6, pages 535–545, December 2011 Abstract The Chinese shar-pei dog is known for its distinctive feature of wrinkled and thickened skin, defined as primary or hereditary cutaneous mucinosis. In a […]

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Cutaneous mucinosis in shar-pei dogs is due to hyaluronic acid deposition and is associated with high levels of hyaluronic acid in serum

Zanna, D. Fondevila, M. Bardagí, M. J. Docampo, A. Bassols and L. Ferrer Veterinary Dermatology Volume 19, Issue 5, pages 314–318, October 2008 Abstract Cutaneous mucinosis affects primarily shar-pei dogs. Hyaluronic acid (HA) is considered to be the main component of mucin and CD44 is the major cell surface receptor of HA, necessary for its uptake and catabolism. The aims of this study […]

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Hereditary cutaneous mucinosis in shar pei dogs is associated with increased hyaluronan synthase-2 mRNA transcription by cultured dermal fibroblasts

Giordana Zanna, María J. Docampo ,Dolors Fondevila, Mar Bardagí, Anna Bassols and Lluís Ferrer Veterinary Dermatology Volume 20, Issue 5-6, pages 377–382, October/December 2009 Abstract Shar pei dogs are known for the distinctive feature of thick, wrinkled skin as a consequence of high dermal mucin content. Excessive dermal deposition of mucinous substance leading to severe […]

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